بحوث سكوبس — سجاد علوان كتاب طراد الغزالي

Background: Breast cancer is a prevalent disease affecting numerous individuals worldwide. This study focuses on investigating the concentration of Ochratoxin A (OTA) in female breast cancer patients in the Al-Najaf Province. Previous research suggests a potential correlation between OTA and breast cancer. Objectives: The objective of this study was to determine the concentration of OTA and its association with breast cancer in females in the Al-Najaf Province. Materials and Methods: A total of 40 female breast cancer patients who received treatment at The National Educational Oncology Hospital in the Al-Najaf Province from April to August 2022 were included in this study. Additionally, 20 healthy females served as the control group. Serum samples were collected in sterile tubes (Eppendorf tube) and analyzed using high-performance liquid chromatography (HPLC) to quantitatively diagnose the OTA ratio. Patient information, including age, was recorded in a data sheet. Results: The results demonstrated a significant increase (P < 0.05) in OTA concentrations among the total number of breast cancer patients compared to the control group. The concentrations of OTA were measured at 0.2720 and 0.2186 ng/mL in breast cancer patients, indicating a higher OTA level in this group. Conclusion: This study provides evidence of a significant association between OTA concentration and breast cancer in female patients from the Al-Najaf Province. These findings contribute to the understanding of the role of OTA in breast cancer development. Further research is warranted to explore the mechanisms underlying this relationship and potentially develop targeted interventions. © 2024 Medical Journal of Babylon | Published by Wolters Kluwer - Medknow S141.

Background: This study aimed to investigate the concentration of ZAN in female breast cancer patients compared to a control group. Objectives: The objective of this study was to determine the concentration of ZAN and its association with breast cancer in female patients treated at the National Educational Oncology Hospital in the Al-Najaf Province. Materials and Methods: A total of 40 female breast cancer patients who were treated at the National Educational Oncology Hospital in the Al-Najaf Province between April and August 2022 were included in the study. Additionally, 20 healthy females served as the control group. High-performance liquid chromatography (HPLC) was used to quantitatively diagnose the ratio of ZAN in the 40 breast cancer cases with positive results. Serum samples were collected in sterile Eppendorf tubes and analyzed using HPLC to determine the concentration of ZAN. Relevant patient information, including age ranges, was recorded in data sheets. Results: The results revealed a significant increase (P < 0.05) in ZAN concentrations among the breast cancer patients compared to the control group. The concentrations of ZAN were measured at 0.345394 and 0.220381 ng/mL, respectively, indicating higher ZAN levels in the breast cancer patient group. Conclusion: This study provides evidence of a significant association between ZAN concentration and breast cancer in female patients treated at the National Educational Oncology Hospital in the Al-Najaf Province. These findings contribute to the understanding of the role of ZAN in breast cancer development. Further research is warranted to explore the mechanisms underlying this relationship and potentially develop targeted interventions. © 2024 Medical Journal of Babylon | Published by Wolters Kluwer - Medknow.

[No abstract available]

Background: Radium-226 and its daughters, such as radon-222 gas, are harmful elements to the human body it is considered a known carcinogen. The present study aimed to determine the physiological effect of radon gas (radium-226 source) on female rats and included the study of some hormone changes. Methods: The study was done on 25 animals aged (8-12) weeks and the weight of (132-208) g. Results: The first group of rats were not exposed to radon gas, which is as control group. While other groups of rats, (four groups) were exposed to radon gas at doses 3063.05 Bq, 4546.86 Bq, 5265.65 Bq, and 613.85 Bq, respectively. Conclusion: The result of body weight shows no significance (P>0.05) in the body weight of rats in groups exposed to radon gas in comparison with the control group. In addition, the result of FSH and LH hormones shows a significant decrease (P<0.05) in groups exposed to radon gas in comparison with the control group, while the estrogen is not significant (P>0.05) in groups exposed to radon gas in comparison with the control group. The study showed a significant increase (p = 0.05) in the body weight of rats groups exposed to radon gas (RAD) groups. Furthermore, the study showed a significant decrease (p = 0.05) in hormones (FSH, LH) and a significant increase (p = 0.05) in hormones (Estrogen) of rats groups exposed to radon gas (RAD) groups in comparison with control groups. © The Authors, published by EDP Sciences, 2024.