The causes of limb amputation vary between developing and developed countries due to differences in healthcare systems, economic conditions, and social environments. In developed countries, many non-traumatic amputations are associated with chronic diseases, particularly diabetes, peripheral arterial disease, and impaired blood circulation, especially among older adults. In developing countries, traumatic injuries caused by road accidents, occupational hazards, armed conflicts, and landmines are significant contributors. Diabetes-related complications and severe infections also increase amputation risks when medical treatment is delayed or healthcare resources are limited. These causes are not exclusive to either group of countries; their prevalence varies according to socioeconomic development and access to medical care. Understanding these differences highlights the importance of prevention, early diagnosis, vascular treatment, rehabilitation, and advanced prosthetic services in reducing amputations and improving patients' quality of life.